Date of submission: 27/05/2022
Colon Adenocarcinoma
NIBRX-2239
Model characterisation
Patient / Tumour Metadata
- Patient Sex
male - Patient Age
70 - 79 - Patient Ethnicity
Not Provided - Tumour Type
Not Provided - Cancer Grade
high - Cancer Stage
T3N0MX - Primary Site
large intestine - Collection Site
distal transverse colon
PDX model engraftment
| HOST STRAIN NAME | SITE | TYPE | MATERIAL | MATERIAL STATUS | PASSAGE |
|---|---|---|---|---|---|
nu/nu | Subcutaneous | Heterotopic | Patient Material/ Direct Inject | Fresh | 0 |
Model quality control
| TECHNIQUE | DESCRIPTION | PASSAGE |
|---|---|---|
| Not Collected | Not Collected | Not Collected |
Model treatment
| DRUG | DOSE | PASSAGE | RESPONSE |
|---|---|---|---|
untreated | 0 | Progressive Disease | |
Cetuximab ChEMBL | 25, 20 mg/kg 25, 20 mg/kg | 0 0 | Progressive Disease Progressive Disease |
LJC049 | 30, 30 mg/kg 30, 30 mg/kg | 0 0 | Progressive Disease Progressive Disease |
250 mg/kg | 0 | Progressive Disease | |
pan-PI3K Inhibitor CLR457 | 20 mg/kg | 0 | Progressive Disease |
LFW527 | 12.5, 10 mg/kg 12.5, 10 mg/kg | 0 0 | Progressive Disease Progressive Disease |
10 mg/kg | 0 | Progressive Disease | |
Cetuximab ChEMBL | 20, 20 mg/kg 20, 20 mg/kg | 0 0 | Stable Disease Stable Disease |
75 mg/kg | 0 | Progressive Disease | |
Cetuximab ChEMBL | 20 mg/kg | 0 | Progressive Disease |
25, 10 mg/kg 25, 10 mg/kg | 0 0 | Stable Disease Stable Disease | |
20 mg/kg | 0 | Progressive Disease | |
25, 20 mg/kg 25, 20 mg/kg | 0 0 | Partial Response Partial Response | |
LJC049 | 30 mg/kg | 0 | Progressive Disease |
50 mg/kg | 0 | Progressive Disease | |
Cetuximab ChEMBL | 25, 20, 20 mg/kg 25, 20, 20 mg/kg 25, 20, 20 mg/kg | 0 0 0 | Stable Disease Stable Disease Stable Disease |
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